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  • Syphilis

    Syphilis Chancre: First Sore Look & Timeline

    A syphilis chancre is the first sore of syphilis: a single, firm, round, painless ulcer that appears at the spot where Treponema pallidum bacteria entered the body — usually the genitals, anus, or mou

    Mark Riegel, MD
  • Syphilis

    Can You Get Syphilis From Oral Sex?

    Yes, you can get syphilis from oral sex. Treponema pallidum , the bacterium that causes syphilis, spreads through direct contact with a syphilis sore — and those sores can sit on the lips, mouth, thro

    Mark Riegel, MD
  • Syphilis

    Syphilis Incubation: How Long Until Symptoms?

    Syphilis has an incubation period of about 10 to 90 days, averaging around three weeks, between exposure and the first painless sore (chancre) of primary syphilis CDC, About Syphilis. After that sore

    Mark Riegel, MD
  • Syphilis

    Jarisch-Herxheimer Reaction After Treatment

    The Jarisch-Herxheimer reaction is a short-lived flare of fever, chills, headache, and muscle aches that appears within the first day after syphilis treatment — usually within a couple of hours of the

    Mark Riegel, MD
  • Syphilis

    Latent Syphilis: Hidden Infection Explained

    Latent syphilis is the symptom-free phase of a Treponema pallidum infection: the bacterium is still alive and detectable on a blood test, but the sores and rash of earlier stages have faded. Clinician

    Mark Riegel, MD
  • Syphilis

    Neurosyphilis: Symptoms, Tests & Treatment

    Neurosyphilis is what happens when Treponema pallidum , the bacterium that causes syphilis, invades the brain, spinal cord, or surrounding fluid. It can appear at any stage of infection, not just late

    Mark Riegel, MD
  • Syphilis

    What Is Syphilis? Causes, Stages & Risks

    Syphilis is a curable bacterial infection caused by Treponema pallidum , spread mainly through sexual contact with an infectious sore and from a pregnant person to their baby. It moves through four st

    Mark Riegel, MD
  • Syphilis

    Syphilis Penicillin Allergy: Treatment Options

    If you're allergic to penicillin and have syphilis, you can usually be treated with doxycycline (100 mg orally twice daily for 14 days for early disease, or 28 days for late latent) instead. The major

    Mark Riegel, MD
  • Syphilis

    How to Prevent Syphilis: Condoms & Doxy-PEP

    You prevent syphilis by combining several layers: use condoms correctly and consistently, limit exposure to untested partners, and screen regularly if you're at risk. For some gay and bisexual men and

    Mark Riegel, MD
  • Syphilis

    Syphilis Reinfection vs Treatment Failure

    A rising syphilis titer after treatment can mean two very different things: reinfection (you cleared the first infection and caught it again, usually from an untreated partner) or treatment failure (t

    Mark Riegel, MD
  • Syphilis

    Syphilis RPR vs Treponemal Test Explained

    Syphilis testing uses two different kinds of blood tests. An RPR is a nontreponemal test that measures the body's reaction to tissue damage and can be tracked as a titer, while a treponemal test detec

    Dr. Amara Okafor, MD MPH
  • Syphilis

    Secondary Syphilis Rash: Palms, Soles & Body

    The secondary syphilis rash is a rough, red or reddish-brown eruption that classically appears on the palms and soles but can spread across the trunk and limbs. It's a sign the infection from Treponem

    Mark Riegel, MD
  • Syphilis

    Syphilis Rates by State 2023: Where Cases Are Rising Fastest

    In 2023 the US primary and secondary (P&S) syphilis rate reached 15.8 per 100,000 CDC AtlasPlus, 2023. Rates vary enormously by state: South Dakota, Washington DC, New Mexico, and Mississippi topped t

    Dr. Amara Okafor, MD MPH
  • Syphilis

    Congenital Syphilis in the US: Cases, Causes & Prevention

    Congenital syphilis happens when syphilis passes from a pregnant person to the fetus through the placenta or during birth. US cases have surged from 2,163 in 2020 to 3,882 in 2023 CDC AtlasPlus, 2023

    Dr. Sarah Chen, MD
  • Syphilis

    Syphilis vs Herpes: Sores, Tests & Treatment

    Syphilis and genital herpes both cause genital sores, but they're fundamentally different. Syphilis is a bacterial infection that produces a single painless, firm sore and is curable with penicillin.

    Mark Riegel, MD
  • Syphilis

    Syphilis Treatment: Penicillin Shots & Cure

    Syphilis is cured with penicillin. For primary, secondary, or early latent disease, that means a single injection of benzathine penicillin G into the muscle; late or unknown-duration syphilis needs th

    Mark Riegel, MD
  • Syphilis

    Syphilis Test: Blood Tests, Timing & Accuracy

    A syphilis test is a blood test, and diagnosis takes two of them: a screening test (RPR or VDRL, or a treponemal antibody test) followed by a different confirmatory test. Antibodies can take up to two

    Mark Riegel, MD
  • Syphilis

    Syphilis Symptoms in Men vs Women

    Syphilis produces the same stages in men and women, but where the first sore lands differs. Men usually get a visible, painless chancre on the penis; women's chancres often sit inside the vagina or on

    Mark Riegel, MD
  • Syphilis

    Syphilis Symptoms: Chancre, Rash & Each Stage

    Syphilis symptoms unfold in stages. The first is usually a single painless sore (chancre) where the bacteria entered, about three weeks after exposure. Weeks later comes a rough rash, often on the pal

    Mark Riegel, MD
  • Syphilis

    Can You Get Syphilis Again After Treatment?

    Yes — you can absolutely get syphilis again after you've been treated and cured. A past infection gives you no immunity to Treponema pallidum , so a new exposure can reinfect you no matter how many ti

    Mark Riegel, MD
  • Syphilis

    Syphilis in Pregnancy & Congenital Syphilis

    Syphilis in pregnancy is a curable bacterial infection that can pass to the baby and cause miscarriage, stillbirth, or lifelong disability — known as congenital syphilis. The fix is straightforward: e

    Dr. Sarah Chen, MD
  • Syphilis

    How Syphilis Spreads: Sex, Kissing & Contact

    Syphilis spreads mainly through direct skin-to-skin contact with an active syphilis sore or rash during vaginal, anal, or oral sex, and from a pregnant person to their baby. The bacterium can't surviv

    Mark Riegel, MD
  • Syphilis

    Can Syphilis Be Cured? Yes, Here's How

    Yes — syphilis is curable at every stage with the right antibiotics. The bacterium Treponema pallidum is reliably killed by penicillin, given as one injection for early infection or three weekly injec

    Mark Riegel, MD
  • Syphilis

    Kissing Can Result In A Positive STD Diagnosis

    A positive STD result almost never comes from a single kiss — it comes from a test that detects an infection you already had, often from another route, and usually with no symptoms to warn you. Most k

    Dr. Amara Okafor, MD MPH
  • Syphilis

    Syphilis in Pregnancy: Screening to Prevent Congenital Cases

    Syphilis in pregnancy is a curable bacterial infection ( Treponema pallidum ) that can pass to the baby and cause miscarriage, stillbirth, or lifelong disability. The fix is straightforward: universal

    Dr. Sarah Chen, MD
  • Syphilis

    Oral Syphilis: Mouth, Throat & Lip Sores

    Oral syphilis refers to sores from Treponema pallidum that show up in the mouth, throat, or lips. In the first stage it's a painless chancre at the site of contact; in the second, mucous patches on th

    Mark Riegel, MD
  • Syphilis

    Untreated Syphilis: Neurosyphilis & Heart Risks

    Untreated syphilis doesn't stay still. After the first sore heals and symptoms fade, the bacterium Treponema pallidum keeps spreading silently, and over years it can damage the heart, blood vessels, b

    Dr. Rohan Patel, PharmD